
Cromoglicic acid
CAS No. 16110-51-3
Cromoglicic acid ( Cromolyn | FPL-670 )
产品货号. M12332 CAS No. 16110-51-3
色甘酸是一种具有抗炎活性的肥大细胞稳定剂,可防止肥大细胞释放炎症化学物质,如组胺、白三烯。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥405 | 有现货 |
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10MG | ¥567 | 有现货 |
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25MG | ¥923 | 有现货 |
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50MG | ¥1353 | 有现货 |
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100MG | ¥2009 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Cromoglicic acid
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述色甘酸是一种具有抗炎活性的肥大细胞稳定剂,可防止肥大细胞释放炎症化学物质,如组胺、白三烯。
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产品描述Cromoglicic acid is a mast cell stabilizer with anti-inflammatory activity that prevents the release of inflammatory chemicals such as histamine, leukotrienes from mast cells; also inhibits chloride channels, and binds S100P to block the interaction between S100P and RAGE.Psoriasis Phase 3 Clinical(In Vitro):Cromolyn sodium (Disodium Cromoglycate; FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack. (In Vivo):Pretreatment of IIR mice with Cromolyn sodium (Disodium Cromoglycate; FPL-670) prior to ischemia exhibited no changes of ET-1 levels, injury score and inflammation (P>0.05, PreCr vs. M groups). In conclusion, administration of Cromolyn (sodium) after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressing sustained MC activation. Cromolyn (sodium) has a role in the prevention of Chronic lung disease(CLD). Cromolyn (sodium) cannot be recommended for the prevention of CLD in preterm infants.
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体外实验——
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体内实验——
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同义词Cromolyn | FPL-670
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Inflammation/Immunology
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适应症Psoriasis
化学信息
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CAS Number16110-51-3
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分子量468.367
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分子式C23H16O11
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纯度>98% (HPLC)
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溶解度——
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SMILESC1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)O)O)C(=O)C=C(O2)C(=O)O
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化学全称5-[3-(2-carboxy-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Heinke S, et al. Br J Pharmacol. 1995 Aug;115(8):1393-8.
2. Zur E, et al. Int J Pharm Compd. 2012 Sep-Oct;16(5):386-93.
3. Penumutchu SR, et al. Biochem Biophys Res Commun. 2014 Nov 21;454(3):404-9.
产品手册




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