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Cromoglicic acid

CAS No. 16110-51-3

Cromoglicic acid ( Cromolyn | FPL-670 )

产品货号. M12332 CAS No. 16110-51-3

色甘酸是一种具有抗炎活性的肥大细胞稳定剂,可防止肥大细胞释放炎症化学物质,如组胺、白三烯。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥405 有现货
10MG ¥567 有现货
25MG ¥923 有现货
50MG ¥1353 有现货
100MG ¥2009 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Cromoglicic acid
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    色甘酸是一种具有抗炎活性的肥大细胞稳定剂,可防止肥大细胞释放炎症化学物质,如组胺、白三烯。
  • 产品描述
    Cromoglicic acid is a mast cell stabilizer with anti-inflammatory activity that prevents the release of inflammatory chemicals such as histamine, leukotrienes from mast cells; also inhibits chloride channels, and binds S100P to block the interaction between S100P and RAGE.Psoriasis Phase 3 Clinical(In Vitro):Cromolyn sodium (Disodium Cromoglycate; FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack. (In Vivo):Pretreatment of IIR mice with Cromolyn sodium (Disodium Cromoglycate; FPL-670) prior to ischemia exhibited no changes of ET-1 levels, injury score and inflammation (P>0.05, PreCr vs. M groups). In conclusion, administration of Cromolyn (sodium) after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressing sustained MC activation. Cromolyn (sodium) has a role in the prevention of Chronic lung disease(CLD). Cromolyn (sodium) cannot be recommended for the prevention of CLD in preterm infants.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    Cromolyn | FPL-670
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Other Targets
  • 研究领域
    Inflammation/Immunology
  • 适应症
    Psoriasis

化学信息

  • CAS Number
    16110-51-3
  • 分子量
    468.367
  • 分子式
    C23H16O11
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)O)O)C(=O)C=C(O2)C(=O)O
  • 化学全称
    5-[3-(2-carboxy-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylic acid

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Heinke S, et al. Br J Pharmacol. 1995 Aug;115(8):1393-8. 2. Zur E, et al. Int J Pharm Compd. 2012 Sep-Oct;16(5):386-93. 3. Penumutchu SR, et al. Biochem Biophys Res Commun. 2014 Nov 21;454(3):404-9.
产品手册
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